Transvection, nuclear structure, and chromatin proteins.
نویسندگان
چکیده
منابع مشابه
Transvection, nuclear structure, and chromatin proteins
ESEARCHERS are inventing and honing the technologies to provide increasingly clear pictures of the organization of the nucleus. One driving issue is the role of chromosome arrangement in gene expression. The intractable nature of this question lies in the fact that it is not yet possible to extract a "chromosome arrangement" and assay it for function. Instead, it must be observed in situ and co...
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As a cell squeezes its nucleus through adjacent tissue, penetrates a basement membrane, or enters a small blood capillary, chromatin density and nuclear factors could in principle be physically perturbed. Here, in cancer cell migration through rigid micropores and in passive pulling into micropipettes, local compaction of chromatin is observed coincident with depletion of mobile factors. Hetero...
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The condensation level of chromatin is controlled by epigenetic modifications and associated regulatory factors and changes throughout differentiation and cell cycle progression. To test whether changes of chromatin condensation levels per se affect access and binding of proteins, we used a hypertonic cell treatment. This shift to hyperosmolar medium increased nuclear calcium concentrations and...
متن کاملNuclear visions enhanced: chromatin structure, organization and dynamics.
The EMBO Workshop on 'Chromatin Structure, Organization and Dynamics' took place in April 2011 in Prague, Czech Republic. Scientists from the life sciences, chemistry and biophysics presented their latest data on the generation of three-dimensional and, eventually, four-dimensional models of the genome, working to correlate changes in the organization of chromatin with the functional state of t...
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Patrick Cramer is a professor of Biochemistry at the Ludwig Maximilians University of Munich, Germany, and head of the Gene Center Munich. He is a structural biologist who has contributed to our understanding of the structure and function of RNAP II from yeast and its associated factors. In a recent study, his laboratory described the structure of RNAP II in complex with the initiation factor T...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1993
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.120.3.587